Antibiotic prophylaxis in cardiac surgery—general principles

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Antibiotic prophylaxis for cardiac surgery.

Antibiotic prophylaxis for cardiac surgery is a controversial area. Recent systematic reviews and meta-analyses of randomized controlled trials have concluded that surgical site infection can be reduced by prolonging prophylaxis for 24-48 h. Also, post-operative pneumonia and all-cause mortality can be reduced by giving agents with both anti-Gram-negative and anti-Gram-positive activity. The ch...

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Does duration of perioperative antibiotic prophylaxis matter in cardiac surgery?

OBJECTIVE We aimed to compare the efficacy of short-term (<24 hours) versus longer-term antibiotic prophylaxis (≥24 hours) in open heart surgery. BACKGROUND The optimal duration of antibiotic prophylaxis for adults undergoing cardiac surgery is unknown and guideline recommendations are inconsistent. METHODS We searched MEDLINE, EMBASE, CINAHL, and CENTRAL for parallel-group randomized trial...

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Antibiotic prophylaxis in cardiac surgery: systematic review and meta-analysis.

BACKGROUND Antibiotic prophylaxis is recommended in cardiac surgery. Current debate concerns the type of antibiotic(s), dosing and the duration of prophylaxis. METHODS Systematic review of randomized controlled trials comparing one antibiotic regimen versus another in cardiac surgery. We searched The Cochrane Library, PubMed, LILACS, conference proceedings and bibliographies. Two reviewers in...

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Perioperative antibiotic prophylaxis in elective surgeries in Iran

  Background : The use of antibiotic prior to surgery is widely accepted. The WHO has recommended the use of ATC/DDD (Anatomical Therapeutic Chemical / Defined Daily Dose) for the analysis of drug utilization.The aims of the present study are 1) to analyze the assessment of prophylactic antibiotic usage prior to surgery, 2) to assess the drug administration based on antibiograms and 3) to compa...

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[Antibiotic prophylaxis in surgery].

One of the more dramatic effects of antimicrobial chemotherapy has been its influence on the practice of modern surgeryl. The use of perioperative antibiotic prophylaxis has been shown to prevent post-surgical wound and other infections. When employed rationally, significant reductions in morbidity and mortality as well as savings in resources can be clearly demonstrated. However; when used exc...

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ژورنال

عنوان ژورنال: APMIS

سال: 2007

ISSN: 0903-4641,1600-0463

DOI: 10.1111/j.1600-0463.2007.00834.x